The non-coding portion of the genome, known as ‘dark matter’, is dynamically active, generating thousands of therapeutically unexplored long non-coding RNAs
IncRNAs are a unique class of regulatory molecules that bridge the analog world of proteins with the digital world of nucleic acids both DNA & RNA to regulate disease associated cellular processes in response to the environment
HAYA has developed proprietary tools and methods to interrogate lncRNA biology, identifying exquisitely tissue- and cell-type specific therapeutic targets
Specific lncRNAs are important regulators of the resting fibroblast to myofibroblast conversion, resulting in fibrosis and disease
The rapid development of anti-fibrotic therapeutics that are safe, effective and accessible.
Our proprietary drug discovery engine enables us to discover and generate a pipeline of lncRNA targeting anti-fibrotic candidates for many tissues including lung, kidney, liver and the tumor microenvironment. These lead targets have the potential for significantly greater efficacy, safety and accessibility than existing treatments