Join Us

The Company

HAYA Therapeutics SA is a precision therapeutics company that discovers and develops innovative tissue- and cell-selective genomic medicines for fibrotic diseases and other serious health conditions associated with aging, including cancer. The Company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of fibrosis and other disease processes -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. HAYA’s lead therapeutic candidate is an antisense molecule targeting Wisper, a cardiac-enriched master driver of fibrosis, which has shown in preclinical testing the ability to halt and potentially reverse the fibrotic processes underlying heart failure. The Company is also developing a pipeline of lncRNA-targeting candidates for the tissue-specific treatment of fibrotic diseases in other tissues, including lungs, kidney, liver, and the micro-environment of solid tumor cancers. Headquartered at the Biopole Science Park in Lausanne, Switzerland, HAYA Therapeutics SA is a rapidly developing innovative company which is led by a world-class team of experts in lncRNA biology and fibrotic disease and is supported by a strong investor consortium.

About the job

We are seeking highly motivated candidates to join our R&D team in Lausanne and contribute to the development and application of advanced technologies in RNA-based therapeutics and diagnostics. 

HAYA seeks candidates who are creative, scientifically bold, independent, goal-oriented, excellent communicators, motivated to learn new skills and work collaboratively in a fast-paced entrepreneurial environment.

Senior Genomic Biomarker Scientist

Responsibilities will include, but are not limited to, the following:

• Build and lead a small team of ~2-3 scientists to drive novel diagnostic and prognostic RNA biomarker discovery studies.
• Design, conceptualize and develop experimental and analytical procedures.
• Lead the strategy,  development, validation and implementation of genetics and genomics-based biomarker assays.
• Be a subject expert in order to evaluate and apply genetics and genomics technologies and assays to ensure we gain relevant insights from precious sample materials.
• Manage all aspects of out-sourced (CROs) work packages.
• Actively participate in internal and external scientific meetings through presentations and critical evaluation of both internal results and emerging scientific literature.
• Inspire your team members and other scientists and train them in the application of new technologies.

Qualifications:

• PhD in molecular and/or RNA biology or related discipline with at least 5 years of experience in biomarker research.
• Strong expertise in genetics and genomics biomarker assays development.
• Deep technical expertise in molecular biology (PCR technologies) and next generation sequencing applications across platforms in various matrices (e.g. tissue, blood, body fluids, cells).
• Strong knowledge with tools, and resources used for the analysis and interpretation of genomic data.
• Proven excellence in building and managing scientific teams and completing challenging projects.
• Excellent organization skills and familiarity with a fast-paced work environment.
• Collaborative spirit and ability to thrive in a matrixed environment.
• Proven track record of handling multiple high priority tasks in parallel with internal and external collaborators.
• Excellent written and verbal communication skills.

Core Values:

• Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge convictions and dogma.
  

• Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
  

• Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.
  

• Fast-acting/efficient. Proactive and quick decision making with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key tasks and priorities. Demonstrates tenacity and willingness to go the distance to get something done.
  

• Integrity. Does not cut corners. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Earns trust and maintains confidences. Expects a high level of personal performance and team performance. Follows-through on commitments.
  

• Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and to independently pursue and achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw key conclusions.
  ‍

Location: Lausanne, Switzerland

Conditions of Employment: Proof of Eligibility to work in Switzerland (Swiss work permit or Swiss / European citizenship)

So, if you think you are a strong fit for this position, please apply today!
Please send your CV and Cover Letter to jobs@hayatx.com. Please specify the position you are applying for.

Excellent salary and benefits package offered.
For more information about HAYA, please visit our website, www.hayatx.com.

The Company

HAYA Therapeutics SA is a precision therapeutics company that discovers and develops innovative tissue- and cell-selective genomic medicines for fibrotic diseases and other serious health conditions associated with aging, including cancer. The Company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of fibrosis and other disease processes -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. HAYA’s lead therapeutic candidate is an antisense molecule targeting Wisper, a cardiac-enriched master driver of fibrosis, which has shown in preclinical testing the ability to halt and potentially reverse the fibrotic processes underlying heart failure. The Company is also developing a pipeline of lncRNA-targeting candidates for the tissue-specific treatment of fibrotic diseases in other tissues, including lungs, kidney, liver, and the micro-environment of solid tumor cancers. Headquartered at the Biopole Science Park in Lausanne, Switzerland, HAYA Therapeutics SA is a rapidly developing innovative company which is led by a world-class team of experts in lncRNA biology and fibrotic disease and is supported by a strong investor consortium.
‍

About the job

We are seeking highly motivated candidates to join our R&D team in Lausanne and contribute to the development and application of advanced technologies in RNA-based therapeutics. You will be joining a highly dynamic scientific team and will focus on generating and experimentally executing actionable pioneering hypotheses to drive novel platform and therapeutic applications.

HAYA seeks candidates who are creative, scientifically bold, independent, goal-oriented, excellent communicators, motivated to learn new skills and work collaboratively in a fast-paced entrepreneurial environment.

Primary responsibilities

• Apply your scientific knowledge, critical thinking skills and creativity to design and execute experiments for the identification of novel lncRNA-targeting therapies in different contests and pathologies.
• Evaluation of the therapeutic potential and efficacy of novel targets using in vitro or in vivo pathological models.
• Aim for rapid proof-of-concept, strategic triage of ideas, and quickly translating new approaches into company assets.
• Develop and apply novel high-throughput methodologies to analyze nucleic acids expression, protein-DNA/RNA interactions, and epigenetic conformations.
• Attend conferences and develop relationships with key opinion leaders.
• Generate, interpret, and present data to the R&D teams and senior managers.
• Maintain an up-to-date electronic notebook record of performed studies.

Requirements
The ideal candidate for this position needs:

• Ph.D. in molecular/cellular/RNA biology (or equivalent)
• 3+ years of relevant experience in RNA biology with a strong background in
  molecular biology, epigenomic and gene transcription regulation.
• Experience in designing, performing, and analyzing a wide array of molecular biology assays including nucleic acid extraction from isolated cells and tissues, qRT-PCR, lentiviral production, CRISPR assays, shRNA and siRNA transfection.
• Proficient with NGS technologies such as ChIP-seq, RNA-seq, PRO-seq, ATAC-seq and scRNA-seq.
• Experience in mammalian primary cell culture and general tissue culture techniques
• Proven track-record of scientific excellence as evidenced by a strong publication and/or patent record
• Proven knowledge of fibrotic diseases and fibroblast biology is a plus.

Location: Lausanne, Switzerland

Conditions of Employment: Proof of Eligibility to work in Switzerland (Swiss work permit or Swiss / European citizenship)

So, if you think you are a strong fit for this position, please apply today!
Please send your CV and Cover Letter to jobs@hayatx.com. Please specify the position you are applying for.

Excellent salary and benefits package offered.
For more information about HAYA, please visit our website, www.hayatx.com.

About us

HAYA Therapeutics is a precision therapeutics company that discovers and develops innovative tissue- and cell-selective genomic medicines for fibrotic diseases and other serious health conditions associated with aging, including cancer. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of fibrosis and other disease processes -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments.
‍

Position summary

We rely on a combination of experimental and computational solutions for target discovery and drug development. We are expanding our computational pipelines to process primary genomic, transcriptomic and epigenomic data. We are looking for a bioinformatician with a solid experience on NGS / RNA-Seq primary (raw) data analysis. As we heavily focus on the non-coding transcriptome, the ideal candidate should be an expert on alignment, de-novo and ab-initio transcript assembly, QC and expression quantification.

Primary responsibilities

• Development of bioinformatic pipelines for the automatic processing of -omic data, in particular RNA-Seq and ChIP-Seq raw data.
• Execution of bioinformatic pipelines on data profiled in-house or from public repositories to identify promising lncRNA targets dysregulated in diseases.
• Support the scientific team in the identification of non-coding transcripts and differential expression analysis.

Beyond these primary tasks, you will be involved in other exciting projects on the analysis of new cutting-edge molecular profiling techniques.

Profile

• Expertise on alignment of RNA-Seq primary data, de-novo and ab-initio transcript assembly, QC and expression quantification.
• PhD in quantitative sciences (e.g. computer science, statistics) or life sciences or several years of professional experience
• Experience with the analysis of primary epigenomic data (e.g. ChIP-Seq) is a strong plus
• Proficiency in Python or R is a plus
• Experience with non-coding genomic or transcriptomic data is a strong plus

Location: Lausanne, Switzerland

Conditions of Employment: Proof of Eligibility to work in Switzerland (Swiss work permit or Swiss / European citizenship)

So, if you think you are a strong fit for this position, please apply today!

Please send your CV and Cover Letter to jobs@hayatx.com

Excellent salary and benefits package offered.
For more information about HAYA, please visit our website, https://www.hayatx.com

About us

HAYA Therapeutics is a precision therapeutics company that discovers and develops innovative tissue- and cell-selective genomic medicines for fibrotic diseases and other serious health conditions associated with aging, including cancer. The company’s discovery engine focuses on long non-coding RNAs (lncRNAs) within the “dark matter” of the human genome -- key tissue and cell-specific drivers of fibrosis and other disease processes -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. HAYA’s lead therapeutic candidate is an antisense molecule targeting Wisper, a cardiac-enriched master driver of fibrosis, which has shown in preclinical testing the ability to halt and potentially reverse the fibrotic processes underlying heart failure. The company is also developing a pipeline of lncRNA-targeting candidates for the tissue-specific treatment of fibrotic diseases in other tissues, including lungs, kidney, liver, and the micro-environment of solid tumor cancers. Headquartered at the Biopole Science Park in Lausanne, Switzerland, HAYA is led by a world-class team of experts in lncRNA biology and fibrotic disease and is supported by a strong investor consortium.

About the job

HAYA is dedicated to leveraging emerging insights in RNA biology to develop a novel class of therapeutics. In this role, you will be an early member of a highly dynamic scientific team generating and experimentally executing on actionable pioneering hypotheses to drive novel platform and therapeutic applications.

HAYA seeks candidates who are creative, scientifically bold, independent, goal-oriented, excellent communicators, motivated to learn new skills and work collaboratively in a fast-paced entrepreneurial environment.

Requirements are a Ph.D. in molecular/cellular/RNA biology (or equivalent), an additional 3+ years of relevant experience, and a proven track-record of scientific excellence as evidenced by a strong publication and/or patent record. The candidate needs a strong background in molecular and RNA biology with experience designing, performing and analyzing a wide array of cell & molecular biology assays and a demonstrated ability to generate innovative hypotheses in unexplored biological fields.

Key Objectives

• Apply your scientific knowledge, critical thinking skills and creativity to generate and test hypotheses for novel applications of our platform in emerging fields of RNA biology.
• Design, execute, and interpret multiple experimental workflows with an emphasis on RNA-centric molecular and cellular techniques.
• Aim for rapid proof-of-concept, strategic triage of ideas, and quickly translating new approaches into company assets.
• Develop and apply novel high-throughput methodologies to analyze nucleic acids, protein expression, and cell phenotypes (experience with single-cell genomic, epigenomic and transcriptomic approaches is desirable)
• Recognize, establish and extend next-generation sequencing approaches to screen and address biological hypotheses.
• Continually cultivate scientific & technical expertise through critical review of the scientific literature, attending external conferences, and developing relationships with key opinion leaders.
• Work collaboratively with a cross-functional biology, technology, and chemistry team to contribute to the vision, strategy, and overall objectives of the company.

Required Skills

• Strong molecular and RNA biology background with extensive hands-on experience in cell-based and molecular biology assays
• Proven track record in novel RNA-centric method development or application, such as RNA-centric NGS methods (i.e. ATAC-Seq, ChIP-Seq, RNA-seq, Ribo-seq, eCLIP, scRNA-seq)
• Excellence in experimental design, execution and interpretation
• Demonstrated ability to approach complex problems with innovative solutions and generate actionable hypotheses
• Experience in high-throughput cell phenotype screening or other massively parallel assay formats
• Working knowledge in relevant statistical and bioinformatics (genomics) methods to enable effective collaboration with computation biology team
• Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
• Strong collaborative skills with evidence of working in, and leading a team

Preferred Skills

• Knowledgeable across a breadth of scientific fields and experience with a broad range of methodologies, such as structure-function relationships in RNA or RNP complexes, or innovative RNA methodologies, e.g. Ribo-seq, RIP-seq, RNA chemical probing.
• Deep understanding of cellular biology and fundamental processes of transcription, gene regulation, chromatic biology, translation, and cell signaling
• Understanding of and experience in proteomics and protein mass spectrometry.

Core Values

• Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge convictions and dogma.
• Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
• Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.
• Fast-acting/efficient. Proactive and quick decision making with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key tasks and priorities. Demonstrates tenacity and willingness to go the distance to get something done.
• Integrity. Does not cut corners. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Earns trust and maintains confidences. Expects a high level of personal performance and team performance. Follows-through on commitments.
• Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and to independently pursue and achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw key conclusions.

‍